Discreet Dolls

Hair-loss drug tied to suicides, depression and anxiety in global study

Carpa

Active member
Aug 27, 2025
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I'm losing hair, but I don't want to go with these meds. I know guys that get surgery and it looks good, but its not cheap.

Finasteride has been linked to depression and suicide for more than 20 years, professor warns Propecia and Proscar

Millions of men undergoing hair loss treatment may be putting their mental health on the line.

Finasteride, a hair-loss drug prescribed for androgenetic alopecia, the most common form of baldness, has been linked to a higher risk of suicide in global studies.

A recent review by Mayer Brezis, a professor at the Hebrew University of Jerusalem, which was published in The Journal of Clinical Psychiatry, argues that there is now enough evidence to mark depression, anxiety and suicidality as genuine risks of the drug.

Finasteride has been linked to depression and suicide for more than 20 years, Brezis revealed, calling attention to the lack of action from manufacturers and regulators.

These concerns were raised in several studies as early as 2002. Four independent analyses and four studies indicating a "significant increase" in depression, anxiety and suicidal behavior were released between 2017 and 2023.

"There has been, therefore, a two-decade delay in the realization of the incidences and the gravity of neuropsychiatric effects, allowing harm from a medicine prescribed for a cosmetic indication of hair loss," the author wrote in the study.

"Over 20 years worldwide, hundreds of thousands may have endured depression, and hundreds may have died by suicide."

Finasteride users have reported ongoing symptoms even after the drug is stopped, including insomnia, panic attacks, cognitive dysfunction and suicidal thoughts.

In a Hebrew University of Jerusalem press release, Brezis reiterated that the evidence of this connection is "no longer anecdotal."

"We now see consistent patterns across diverse populations. And the consequences may have been tragic," he said.

"The lesson is that before approving a medication for the market, regulators should require manufacturers to commit to performing and disclosing ongoing post-approval analytical studies, and this requirement needs to be enforced," Brezis concluded in the review.

In 2011, the FDA reportedly acknowledged depression as a potential side effect of finasteride, adding suicidality in 2022.

The agency recorded 18 suicides linked to finasteride in 2011, although Brezis argued that the number should have "ranged in the thousands."

In an additional statement sent to Fox News Digital, Brezis confirmed that physicians frequently prescribe finasteride "offhandedly because they are not aware of its risks."

 

The Oracle

Pronouns: Who/Cares
Mar 8, 2004
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On the slopes of Mount Parnassus, Greece
Also used for BPH . Finasteride is a type of medicine called a 5-alpha reductase inhibitor. It works by stopping testosterone (a sex hormone) turning into another hormone called dihydrotestosterone (DHT)
 
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SchlongConery

License to Shill
Jan 28, 2013
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Maybe they're depressed because they're bald.

This could be more true than not.

I'm fortunate in that my genes have given me a nice, full head of hair. But I imagine that if I was susceptible to hair loss, I'd just accept it, shave my head and embrace that look. But that's just me. I do understand that many guys do suffer significant emotional duress over losing their hair.
 

Brightside89

Active member
May 3, 2025
151
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I'm losing hair, but I don't want to go with these meds. I know guys that get surgery and it looks good, but its not cheap.

Finasteride has been linked to depression and suicide for more than 20 years, professor warns Propecia and Proscar

Millions of men undergoing hair loss treatment may be putting their mental health on the line.

Finasteride, a hair-loss drug prescribed for androgenetic alopecia, the most common form of baldness, has been linked to a higher risk of suicide in global studies.

A recent review by Mayer Brezis, a professor at the Hebrew University of Jerusalem, which was published in The Journal of Clinical Psychiatry, argues that there is now enough evidence to mark depression, anxiety and suicidality as genuine risks of the drug.

Finasteride has been linked to depression and suicide for more than 20 years, Brezis revealed, calling attention to the lack of action from manufacturers and regulators.

These concerns were raised in several studies as early as 2002. Four independent analyses and four studies indicating a "significant increase" in depression, anxiety and suicidal behavior were released between 2017 and 2023.

"There has been, therefore, a two-decade delay in the realization of the incidences and the gravity of neuropsychiatric effects, allowing harm from a medicine prescribed for a cosmetic indication of hair loss," the author wrote in the study.

"Over 20 years worldwide, hundreds of thousands may have endured depression, and hundreds may have died by suicide."

Finasteride users have reported ongoing symptoms even after the drug is stopped, including insomnia, panic attacks, cognitive dysfunction and suicidal thoughts.

In a Hebrew University of Jerusalem press release, Brezis reiterated that the evidence of this connection is "no longer anecdotal."

"We now see consistent patterns across diverse populations. And the consequences may have been tragic," he said.

"The lesson is that before approving a medication for the market, regulators should require manufacturers to commit to performing and disclosing ongoing post-approval analytical studies, and this requirement needs to be enforced," Brezis concluded in the review.

In 2011, the FDA reportedly acknowledged depression as a potential side effect of finasteride, adding suicidality in 2022.

The agency recorded 18 suicides linked to finasteride in 2011, although Brezis argued that the number should have "ranged in the thousands."

In an additional statement sent to Fox News Digital, Brezis confirmed that physicians frequently prescribe finasteride "offhandedly because they are not aware of its risks."

I'm balding recently and I have started using low dose topical cream mix of minoxidil and finasteride and coincidentally I haven't been feeling my usual self the last two months I have been using it but I doubt the little topical dose can the effect talked about inthe study, i think people in the study used oral finasteride.
 

Carpa

Active member
Aug 27, 2025
143
79
28
I'm balding recently and I have started using low dose topical cream mix of minoxidil and finasteride and coincidentally I haven't been feeling my usual self the last two months I have been using it but I doubt the little topical dose can the effect talked about inthe study, i think people in the study used oral finasteride.
Maybe switch to minoxidil alone..
 

Phil C. McNasty

Go Jays Go
Dec 27, 2010
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I'm balding recently and I have started using low dose topical cream mix of minoxidil and finasteride and coincidentally I haven't been feeling my usual self the last two months I have been using it but I doubt the little topical dose can the effect talked about inthe study, i think people in the study used oral finasteride
You can buy topical finasteride, and I heard it works just as good as the oral pill version minus the side effects

 
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jeff2

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Sep 11, 2004
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You can buy topical finasteride, and I heard it works just as good as the oral pill version minus the side effects

Did not know about that. Something to consider.

 

The Oracle

Pronouns: Who/Cares
Mar 8, 2004
30,223
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On the slopes of Mount Parnassus, Greece
I'm balding recently and I have started using low dose topical cream mix of minoxidil and finasteride and coincidentally I haven't been feeling my usual self the last two months I have been using it but I doubt the little topical dose can the effect talked about inthe study, i think people in the study used oral finasteride.

Oral yes in this study.

Still you have to wonder what the transdermal effect of a topical preparation would be.

And this what AI says about that

'' Yes, topical finasteride can have a transdermal effect, meaning it can be absorbed through the skin and into the bloodstream, potentially leading to systemic side effects similar to those of oral finasteride, such as erectile dysfunction and depression. However, research indicates that the systemic absorption from topical formulations is generally lower, with one study noting maximum plasma finasteride concentrations were over 100-fold lower than with the oral version ''
 
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lomotil

Well-known member
Mar 14, 2004
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Oblivion
Maybe they're depressed because they're bald.
This !
Some gentleman are already depressed because they are balding, which is definitely a cofactor in this medication associated suicide story.
Other suicide cofactors would be erectile dysfunction, increased waistline, lose of teeth, diminished appeal to the opposite sex, inability to accept their aging process, long term unhappy marriages etc.
Almost all medications associated with age related medical concerns and / or mental issues have precautions regarding increased suicidal thoughts more than medications for other maladies.

Mori Momento….….
 
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Birf

I done told you
May 29, 2025
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I'm balding recently and I have started using low dose topical cream mix of minoxidil and finasteride and coincidentally I haven't been feeling my usual self the last two months I have been using it but I doubt the little topical dose can the effect talked about inthe study, i think people in the study used oral finasteride.
This reminds me when someone tells you you haven't been yourself lately, you respond by saying 'what are telling me for then'.
 
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