My own 2 cents:
I have a strong preference for playing with natural breasts. On the one hand, they're far more responsive, and on the other they just feel.... well, natual... Right. Not wrong. There's no other way to describe it.
I've had experiences with what I thought were very good implants (visually), that even passed early touch tests, but then as things were getting toward an interesting point, getting that feel of alien "wrongness", which just spoiled the mood.
Having said that, while I certainly have a preference, I doubt that I'd reject an attractive woman merely on the basis of her having implants. And, as a part of that, whatever makes you feel sexy and confident will, in fact, cause you to be confident, and therefore sexy, and way more likely to catch eyes and turn heads.
PS - If you're worried about the extra-skin effect from weight loss, I'd recommend using a Vitamin E lotion, which helps skin elasticity and toning. It's not magic, mind you, but it seems to help (at least, it helped with my weight loss).